| First Author | Laronga C | Year | 2000 |
| Journal | J Biol Chem | Volume | 275 |
| Issue | 30 | Pages | 23106-12 |
| PubMed ID | 10767298 | Mgi Jnum | J:64823 |
| Mgi Id | MGI:1890017 | Doi | 10.1074/jbc.M905616199 |
| Citation | Laronga C, et al. (2000) Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression. J Biol Chem 275(30):23106-12 |
| abstractText | 14-3-3 sigma, implicated in cell cycle arrest by p53, was cloned by expression cloning through cyclin-dependent kinase 2 (CDK2) association. 14-3-3 sigma shares cyclin-CDK2 binding motifs with different cell cycle regulators, including p107, p130, p21(CIP1), p27(KIP1), and p57(KIP2), and is associated with cyclin.CDK complexes in vitro and in vivo. Overexpression of 14-3-3 sigma obstructs cell cycle entry by inhibiting cyclin-CDK activity in many breast cancer cell lines. Overexpression of 14-3-3 sigma can also inhibit cell proliferation and prevent anchorage-independent growth of these cell lines. These findings define 14-3-3 sigma as a negative regulator of the cell cycle progression and suggest that it has an important function in preventing breast tumor cell growth. |
