| First Author | Martínez G | Year | 2016 |
| Journal | Cell Rep | Volume | 14 |
| Issue | 6 | Pages | 1382-1394 |
| PubMed ID | 26854229 | Mgi Jnum | J:323533 |
| Mgi Id | MGI:6837896 | Doi | 10.1016/j.celrep.2016.01.028 |
| Citation | Martinez G, et al. (2016) Regulation of Memory Formation by the Transcription Factor XBP1. Cell Rep 14(6):1382-1394 |
| abstractText | Contextual memory formation relies on the induction of new genes in the hippocampus. A polymorphism in the promoter of the transcription factor XBP1 was identified as a risk factor for Alzheimer's disease and bipolar disorders. XBP1 is a major regulator of the unfolded protein response (UPR), mediating adaptation to endoplasmic reticulum (ER) stress. Using a phenotypic screen, we uncovered an unexpected function of XBP1 in cognition and behavior. Mice lacking XBP1 in the nervous system showed specific impairment of contextual memory formation and long-term potentiation (LTP), whereas neuronal XBP1s overexpression improved performance in memory tasks. Gene expression analysis revealed that XBP1 regulates a group of memory-related genes, highlighting brain-derived neurotrophic factor (BDNF), a key component in memory consolidation. Overexpression of BDNF in the hippocampus reversed the XBP1-deficient phenotype. Our study revealed an unanticipated function of XBP1 in cognitive processes that is apparently unrelated to its role in ER stress. |
