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Protein Domain : Shiga-like toxin, subunit A

Primary Identifier  IPR016331 Type  Family
Short Name  Shiga-like_toxin_subunit_A
description  This entry represents subunit A of Shiga-like toxin also known as rRNA N-glycosidase; ), which are responsible for inactivation of the ribosome. Shiga-like toxins are produced by Shigella dysenteriae and by bacteriophage that infect Escherichia coli cells []. These toxins contain a single A subunit that has N-glycosidase activity and multiple copies of the B subunit that binds to the membrane glycolipid, globotriaosylceramide (Gb3). The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. It catalyses the endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.

0 Child Features

1 Parent Features

0 Protein Domain Regions