| First Author | Coutelier JP | Year | 1995 |
| Journal | J Virol | Volume | 69 |
| Issue | 3 | Pages | 1955-8 |
| PubMed ID | 7853541 | Mgi Jnum | J:22789 |
| Mgi Id | MGI:70677 | Doi | 10.1128/jvi.69.3.1955-1958.1995 |
| Citation | Coutelier JP, et al. (1995) Interleukin-12 gene expression after viral infection in the mouse. J Virol 69(3):1955-8 |
| abstractText | Interleukin-12 is a lymphokine that triggers gamma interferon secretion by various cells and differentiation of T-helper lymphocytes towards the Th1 subtype. Since viruses are potent inducers of gamma interferon production and elicit immune responses most probably mediated by Th1 cells, like B-cell immunoglobulin G2a secretion, we analyzed interleukin-12 message expression after infection of mice with lactate dehydrogenase-elevating virus, mouse hepatitis virus, and mouse adenovirus. Our results indicated that the message for the p40 component of interleukin-12 was transiently increased shortly after infection. Interleukin-12 was expressed mainly by macrophages. Therefore, production of interleukin-12 might constitute the initial event that would determine the subsequent characteristics of the immune response elicited by viral infections. |
