Primary Identifier | MGI:1922670 | Organism | mouse, laboratory |
Chromosome | 13 | NCBI Gene Number | 75420 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ribonucleoprotein complex binding activity and selenocysteine insertion sequence binding activity. Acts upstream of or within forebrain development and regulation of gene expression. Located in mitochondrion. Part of ribonucleoprotein complex. Is expressed in cerebellum; retina inner nuclear layer; and retina outer nuclear layer. Human ortholog(s) of this gene implicated in thyroid gland disease. Orthologous to human SECISBP2 (SECIS binding protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete preweaning lethality while heterozygotes exhibit reduced serum selenium levels. [provided by MGI curators] |