Primary Identifier | MGI:7547005 | Allele Type | Targeted |
Attribute String | Conditional ready, Constitutively active, Epitope tag, Inserted expressed sequence | Gene | Gt(ROSA)26Sor |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A loxP-flanked stop cassette (LSL) and Akt1 cDNA containing a glutamic acid to lysine substitution at amino acid 17 (p.E17K) with an N-terminal Flag tag were inserted into the locus. The pE17K mutation renders constitutive activation of AKT1. Cre mediated recombination is required to induce expression of the constitutively active AKT1. |