| First Author | Dudek BC | Year | 1994 |
| Journal | Pharmacol Biochem Behav | Volume | 48 |
| Issue | 3 | Pages | 593-600 |
| PubMed ID | 7938111 | Mgi Jnum | J:19391 |
| Mgi Id | MGI:67555 | Doi | 10.1016/0091-3057(94)90319-0 |
| Citation | Dudek BC, et al. (1994) Genetic influences on locomotor activating effects of ethanol and sodium pentobarbital. Pharmacol Biochem Behav 48(3):593-600 |
| abstractText | The paradoxical capability of sedative-hypnotics to produce behavioral disinhibition varies among genotypes. In DBA/2 mice ethanol (ETOH) produced strong locomotor stimulation with the peak of the biphasic curve at 1.5 g/kg IP. C57BL/6 mice showed no activation, and F1S were intermediate. These characterizations held for a variety of behavioral indices derived from 15 min tests, such as distance, speed, and rest time, at doses in the 0-2.0 g/kg range. Analogous studies with sodium pentobarbital (0-40 mg/kg) yielded a similar pattern of strain differences in locomotor stimulation. In contrast, loss of righting reflex durations (60 mg/kg PENTO, IP) were similar in the two strains, indicating dissociation of activating and sedative effects. In complementary studies, long- and short-sleep mice, which were bred for differences in soporific effects of ETOH, showed similar activation profiles at ETOH doses up to 1.5 g/kg and PENTO doses up to 30 mg/kg. These studies provide support for an hypothesis of common genetic control of the activation effect for ETOH and PENTO. |
