| Primary Identifier | MGI:1931595 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 80859 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Involved in several processes, including lymphocyte activation involved in immune response; positive regulation of immune response; and response to bacterium. Acts upstream of or within inflammatory response. Is active in nucleus. Is expressed in central nervous system; early conceptus; eye; and genitourinary system. Used to study Stevens-Johnson syndrome and atopic dermatitis. Orthologous to human NFKBIZ (NFKB inhibitor zeta). PHENOTYPE: Homozygous inactivation of this gene may lead to background sensitive prenatal lethality and results in abnormal cytokine secretion, higher IgE levels, ocular surface and perioral skin inflammation accompanied by hair loss, and severe atopic dermatitis-like skin lesions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
