| First Author | Kitamura H | Year | 2000 |
| Journal | FEBS Lett | Volume | 485 |
| Issue | 1 | Pages | 53-6 |
| PubMed ID | 11086164 | Mgi Jnum | J:65974 |
| Mgi Id | MGI:1927684 | Doi | 10.1016/s0014-5793(00)02185-2 |
| Citation | Kitamura H, et al. (2000) MAIL, a novel nuclear IkappaB protein that potentiates LPS-induced IL-6 production. FEBS Lett 485(1):53-6 |
| abstractText | We have identified and characterized a novel member of the ankyrin-repeat family named 'molecule possessing ankyrin-repeats induced by lipopolysaccharide' (MAIL). The C-terminal portion of MAIL shared high sequence homology with the IkappaB family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (<0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells. These findings indicate that MAIL is one of the nuclear IkappaB proteins and an activator of IL-6 production. |
