First Author | Washbourne P | Year | 2002 |
Journal | Nat Neurosci | Volume | 5 |
Issue | 1 | Pages | 19-26 |
PubMed ID | 11753414 | Mgi Jnum | J:73755 |
Mgi Id | MGI:2156357 | Doi | 10.1038/nn783 |
Citation | Washbourne P, et al. (2002) Genetic ablation of the t-SNARE SNAP-25 distinguishes mechanisms of neuroexocytosis. Nat Neurosci 5(1):19-26 |
abstractText | Axon outgrowth during development and neurotransmitter release depends on exocytotic mechanisms, although what protein machinery is common to or differentiates these processes remains unclear. Here we show that the neural t-SNARE (target-membrane-associated-soluble N-ethylmaleimide fusion protein attachment protein (SNAP) receptor) SNAP-25 is not required for nerve growth or stimulus-independent neurotransmitter release, but is essential for evoked synaptic transmission at neuromuscular junctions and central synapses. These results demonstrate that the development of neurotransmission requires the recruitment of a specialized SNARE core complex to meet the demands of regulated exocytosis. |