| Primary Identifier | MGI:2179435 | Organism | mouse, laboratory |
| Chromosome | 3 | NCBI Gene Number | 192167 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables neurexin family protein binding activity. Involved in several processes, including positive regulation of transport; regulation of postsynapse organization; and synapse organization. Acts upstream of or within several processes, including positive regulation of synapse assembly; regulation of respiratory gaseous exchange by nervous system process; and synapse organization. Located in external side of plasma membrane and synapse. Part of protein complex involved in cell-cell adhesion and receptor complex. Is active in glutamatergic synapse. Is expressed in blood vessel and brain. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human NLGN1 (neuroligin 1). PHENOTYPE: Mice homozygous for a knock-out allele are viable and fertile but display impaired NMDA receptor-mediated synaptic transmission onto CA1 pyramidal cells. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
