| Primary Identifier | IPR033493 | Type | Family |
| Short Name | NDEL1 |
| description | NDE-like 1 (NDEL1/NUDEL) and its paralogue, NDE, are involved in mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders. NDEL1 contains the N-terminal LIS1-binding domain that stimulates the movement of dynein and the C-terminal domain that causes dynein-microtubule dissociation [, , ]. It can also bind the motor domain of dynein in its heavy-chain []. It has been shown to affect many aspects of dynein function, such as transport along the microtubule network of vesicles and lysosomes, with effects on the correct structure of the Golgi apparatus, as well as on the transport of intermediate filament proteins, short microtubules and viral glycoproteins. Its phosphorilation by Aurora-A kinase is essential for centrosomal separation and mitotic entry []. It also facilitates neurofilament polymerization, promotes axonal regeneration, regulates Cdc42 at the leading edge of migrating neurons and the GTPase activity of the microtubule remodeling protein Dynamin 2, etc [, ]. |
