| Primary Identifier | IPR037582 | Type | Family |
| Short Name | EIF4EBP1 |
| description | This entry represents eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1). EIF4EBP1 is a repressor of translation that binds to EIF4E and prevents its assembly into the eIF4F complex. EIF4EBP1 has to be hypophosphorylated to bind to EIF4E; the hyperphosphorylated form dissociates from EIF4E []. The phosphorylation state of EIF4EBP1 is affected by hormones such as insulin []and is regulated by mTORC1 []. When eIF4E levels are low, hypophosphorylated EIF4EBP1 is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation, and translation is maintained []. |
