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Publication : Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.

First Author  Melum E Year  2011
Journal  Nat Genet Volume  43
Issue  1 Pages  17-9
PubMed ID  21151127 Mgi Jnum  J:169033
Mgi Id  MGI:4939563 Doi  10.1038/ng.728
Citation  Melum E, et al. (2011) Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci. Nat Genet 43(1):17-9
abstractText  Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 x 10(1) and P = 4.1 x 10, respectively).
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