| First Author | Peyrard M | Year | 1994 |
| Journal | Hum Mol Genet | Volume | 3 |
| Issue | 8 | Pages | 1393-9 |
| PubMed ID | 7987321 | Mgi Jnum | J:59619 |
| Mgi Id | MGI:1351973 | Doi | 10.1093/hmg/3.8.1393 |
| Citation | Peyrard M, et al. (1994) Characterization of a new member of the human beta-adaptin gene family from chromosome 22q12, a candidate meningioma gene. Hum Mol Genet 3(8):1393-9 |
| abstractText | A 140 kb homozygous deletion from 22q12 in one meningioma directed us towards the cloning and characterization of a new member of the human beta-adaptin gene family (named BAM22). Adaptins are essential for the formation of clathrin coated vesicles in the course of intracellular transport of receptor-ligand complexes. The BAM22 gene is totally inactivated in the tumor with homozygous deletion. Northern blot analysis of 70 sporadic meningiomas showed specific loss of expression in 8 tumors, suggesting inactivation of BAM22. Based on this, we propose BAM22 as a second chromosome 22 locus important in meningioma development, after the neurofibromatosis type 2 gene. |
