Primary Identifier | MGI:6159170 | Allele Type | Endonuclease-mediated |
Attribute String | Hypomorph | Gene | Tyr |
Strain of Origin | (B6(Cg)-Tyr<c-2J> x C57BL/6J)F1 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | CRISPR/Cas9 mediated mutagenesis created a 15 bp in-frame deletion in a region proximal to the 5' end of exon 1 resulting in a 5 amino acid deletion (GPQFPFKGVDDRESW to GPQLDDRESW) and a 3 bp in-frame deletion resulting in a loss of threonine at position 244. |