| First Author | Roelink H | Year | 1993 |
| Journal | Genomics | Volume | 17 |
| Issue | 3 | Pages | 790-2 |
| PubMed ID | 8244403 | Mgi Jnum | J:14561 |
| Mgi Id | MGI:62726 | Doi | 10.1006/geno.1993.1412 |
| Citation | Roelink H, et al. (1993) Molecular cloning and chromosomal localization to 17q21 of the human WNT3 gene. Genomics 17(3):790-2 |
| abstractText | In mouse mammary tumors, the Wnt-3 gene can be activated by proviral insertion. Here we report on the isolation of a human homolog, WNT3. A genomic clone was isolated by use of mouse Wnt-3 sequences as a probe, after which cDNA containing most of the protein-encoding domain of the human gene was obtained by PCR. Comparison between the deduced mouse and human WNT-3 protein sequences showed four changes in 333 amino acids. WNT3 is located on chromosome 17q21. The gene was not found to be amplified or rearranged in a collection of human breast tumors. |
