| First Author | Girardi M | Year | 2001 |
| Journal | Science | Volume | 294 |
| Issue | 5542 | Pages | 605-9 |
| PubMed ID | 11567106 | Mgi Jnum | J:88981 |
| Mgi Id | MGI:3037535 | Doi | 10.1126/science.1063916 |
| Citation | Girardi M, et al. (2001) Regulation of cutaneous malignancy by gammadelta T cells. Science 294(5542):605-9 |
| abstractText | The localization of gammadelta T cells within epithelia suggests that these cells may contribute to the down-regulation of epithelial malignancies. We report that mice lacking gammadelta cells are highly susceptible to multiple regimens of cutaneous carcinogenesis. After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA. Each of these is a ligand for NKG2d, a receptor expressed by cytolytic T cells and natural killer (NK) cells. In vitro, skin-associated NKG2d+ gammadelta cells killed skin carcinoma cells by a mechanism that was sensitive to blocking NKG2d engagement. Thus, local T cells may use evolutionarily conserved proteins to negatively regulate malignancy. |
