Primary Identifier | MGI:87854 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 11287 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables endopeptidase inhibitor activity. Acts upstream of or within embryo implantation. Located in collagen-containing extracellular matrix. Is expressed in liver and liver lobe. PHENOTYPE: Homozygotes mutant null mice show higher bone mineral density, hypoactivity, and decreased heart rate. Mice homozygous for a different null allele show resistance to the lethal effects of endotoxin, increased susceptibility to diet-induced acute pancreatitis, and altered LPS-induced febrile and cytokine responses. [provided by MGI curators] |