| First Author | de Chaldée M | Year | 2006 |
| Journal | Genomics | Volume | 87 |
| Issue | 2 | Pages | 200-7 |
| PubMed ID | 16359841 | Mgi Jnum | J:105793 |
| Mgi Id | MGI:3616518 | Doi | 10.1016/j.ygeno.2005.10.009 |
| Citation | de Chaldee M, et al. (2006) Capucin: a novel striatal marker down-regulated in rodent models of Huntington disease. Genomics 87(2):200-7 |
| abstractText | In an initial study, we compared quantitative transcriptome data across mouse brain territories using the serial analysis of gene expression method. Among the novel regional markers that we discovered, we focused on a striatum-enriched transcript with no available experimental cDNA sequence. Here, we report its cloning, gene structure, and detailed distribution in mouse brain. Quantitative RT-PCR and in situ hybridization demonstrated predominant expression in dorsolateral striatum. We therefore named it capucin for caudate-and putamen-enriched sequence. Mouse capucin is a 237-amino-acid protein, without any registered ortholog in mammalian species. It contains no recognizable motif other than two predicted carboxy-terminal transmembrane domains. When expressed in fusion with a fluorescent protein, it localized to the Golgi apparatus in two mammalian cell lines. Interestingly, we observed a significant down-regulation of capucin mRNA levels in two rodent models of Huntington disease, indicating a possible contribution to the pathogenesis of this disorder. |
