| First Author | Kwakkenbos MJ | Year | 2004 |
| Journal | Immunogenetics | Volume | 55 |
| Issue | 10 | Pages | 655-66 |
| PubMed ID | 14647991 | Mgi Jnum | J:87940 |
| Mgi Id | MGI:3028718 | Doi | 10.1007/s00251-003-0625-2 |
| Citation | Kwakkenbos MJ, et al. (2004) The EGF-TM7 family: a postgenomic view. Immunogenetics 55(10):655-66 |
| abstractText | With the human and mouse genome projects now completed, the receptor repertoire of mammalian cells has finally been elucidated. The EGF-TM7 receptors are a family of class B seven-span transmembrane (TM7) receptors predominantly expressed by cells of the immune system. Within the large TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique. Derived from the processing of a single polypeptide, they are expressed at the cell surface as heterodimers consisting of a large extracellular region associated with a TM7 moiety. Through a variable number of N-terminal epidermal growth factor (EGF)-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate. Recent in vivo studies demonstrate a role of the EGF-TM7 receptor CD97 in leukocyte migration. The different number of EGF-TM7 genes in man compared with mice, the chimeric nature of EMR2 and the inactivation of human EMR4 point toward a still-evolving receptor family. Here we discuss the currently available information on this intriguing receptor family. |
