Primary Identifier | MGI:1921407 | Organism | mouse, laboratory |
Chromosome | 17 | NCBI Gene Number | 74157 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable mRNA (nucleoside-2'-O-)-methyltransferase activity. Predicted to be involved in 7-methylguanosine mRNA capping and cap1 mRNA methylation. Predicted to act upstream of or within mRNA processing. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; olfactory epithelium; and retina. Orthologous to human CMTR1 (cap methyltransferase 1). PHENOTYPE: Homozygous knockout is early embryonic lethal. Conditional homozygous KO in neurons leads to reduced neocortex size and neurite dysmorphology. [provided by MGI curators] |