| Primary Identifier | MGI:99500 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 13850 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables epoxide hydrolase activity. Involved in several processes, including cholesterol homeostasis; epoxide metabolic process; and regulation of cholesterol metabolic process. Predicted to be located in cytosol. Predicted to be active in peroxisome. Is expressed in several structures, including eye; heart; integumental system; nervous system; and urinary system. Human ortholog(s) of this gene implicated in coronary artery disease; familial hypercholesterolemia; and hypertension. Orthologous to human EPHX2 (epoxide hydrolase 2). PHENOTYPE: Males homozygous for a targeted null mutation display a significant reduction in blood pressure both in the absence and presence of dietary salt loading. Both sexes exhibit altered arachidonic acid metabolism and reduced renal formation of epoxyeicosatrienoic and dihydroxyeicosatrienoic acids. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
