| First Author | Campbell J | Year | 2012 |
| Journal | J Leukoc Biol | Volume | 92 |
| Issue | 5 | Pages | 933-7 |
| PubMed ID | 22730545 | Mgi Jnum | J:189532 |
| Mgi Id | MGI:5446081 | Doi | 10.1189/jlb.1211635 |
| Citation | Campbell J, et al. (2012) Transient CD8-memory contraction: a potential contributor to latent cytomegalovirus reactivation. J Leukoc Biol 92(5):933-7 |
| abstractText | It is clear that latent CMV can reactivate in immunocompetent individuals, but the mechanism triggering such reactivations remains unclear. Recent clinical data suggest that reactivation can be subverted by CMV-specific T-memory. We therefore monitored CMV-specific T cells in immunocompetent mice with latent mCMV after a known reactivation trigger (LPS). LPS induced transient systemic contraction of mCMV-specific CD8 memory that was followed by transcriptional reactivation. Subsequent recovery of mCMV-specific T cells coincided with resumption of latency. These data suggest that bacterial antigen encounters can induce transient T-memory contraction, allowing viral recrudescence in hosts latently infected with herpes family viruses. |
