| Primary Identifier | MGI:2150019 | Organism | mouse, laboratory |
| Chromosome | 11 | NCBI Gene Number | 114716 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein kinase binding activity; protein serine/threonine kinase inhibitor activity; and stem cell factor receptor binding activity. Involved in negative regulation of cell differentiation; regulation of protein modification process; and regulation of signal transduction. Acts upstream of or within negative regulation of MAPK cascade. Located in cytoplasmic vesicle and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; heart; and sensory organ. Used to study achondroplasia. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human SPRED2 (sprouty related EVH1 domain containing 2). PHENOTYPE: Homozygous null mice are fertile and display increased hematopoietic cell formation in culture. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
