| Type | MGI:General | Description | despite normal hippocampal histology (at E15, P2, and P34), homozygotes show increased susceptibility to pentylenetetrazole (PTZ)- and kainic acid-induced seizures relative to wild-type control mice whereas administration of 30 mg/kg of PTZ fails to induce convulsive behavior in wild-type mice, it induces clonic-tonic seizures in 52% of similarly-treated mutant mice in response to 20 mg/kg kainic acid, mutant mice display normal changes in motor behavior (including myoclonic twitching in the head, face and fore-limbs that often develops into generalized clonic-tonic seizures) relative to wild-type mice; however, mutant mice show significantly shorter latencies to generalized seizures, a signicantly prolonged convulsive phase (with frequent rearing, falling over to one side, and oral foam) and a mortality rate of >75% within 24 hrs post-treatment relative to <10% in wild-type mice increased sensitivity to convulsant stimuli is attributed to a 40% increase in adenosine A1 receptors in the hippocampus and other subtle changes in neural plasticity during development |
