| First Author | Fiorito V | Year | 2015 |
| Journal | Antioxid Redox Signal | Volume | 23 |
| Issue | 18 | Pages | 1410-23 |
| PubMed ID | 26067085 | Mgi Jnum | J:339071 |
| Mgi Id | MGI:7519284 | Doi | 10.1089/ars.2014.6216 |
| Citation | Fiorito V, et al. (2015) Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis. Antioxid Redox Signal 23(18):1410-23 |
| abstractText | AIMS: The maintenance of heme homeostasis, mucosa cell renewal, and redox environment in the intestine is essential to permit digestion, absorption, cell proliferation, cell apoptosis, and immune response and to avoid the development of gut disorders. The feline leukemia virus, subgroup C, receptor 1a (FLVCR1a) is a heme exporter expressed in almost all cell types, including intestinal cells. This work investigates the role of FLVCR1a in the intestine, taking advantage of an intestine-specific conditional Flvcr1a-knockout mouse and of FLVCR1a-depleted Caco2 cells. RESULTS: The data show that FLVCR1a does not participate in the absorption of dietary heme, whereas it is involved in the export of de novo synthesized heme from intestinal cells. The loss of Flvcr1a is associated with a decrease of intestinal cell proliferation and with alterations in the peculiar homeostasis of proliferating cells, including the maintenance of their redox status. The involvement of FLVCR1a in these processes renders this exporter crucial for the survival of mice in a model of ulcerative colitis. INNOVATION: These findings shed light on the role of heme export in the dietary heme absorption process and unravel a new role for heme export in the control of mucosal renewal and in proliferating cell redox status and metabolic activity, demonstrating a crucial role for FLVCR1a in maintaining intestinal homeostasis in both physiologic and pathologic situations. CONCLUSION: By exporting the excess of de novo synthesized heme from intestinal cells, FLVCR1a participates in the control of intestinal mucosa homeostasis. |
