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Publication : Initial sequencing and comparative analysis of the mouse genome.

First Author  Mouse Genome Sequencing Consortium. Year  2002
Journal  Nature Volume  420
Issue  6915 Pages  520-62
PubMed ID  12466850 Mgi Jnum  J:80507
Mgi Id  MGI:2445986 Doi  10.1038/nature01262
Citation  Waterston RH, et al. (2002) Initial sequencing and comparative analysis of the mouse genome. Nature 420(6915):520-62
abstractText  The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report the results of an international collaboration to produce a high-quality draft sequence of the mouse genome. We also present an initial comparative analysis of the mouse and human genomes, describing some of the insights that can be gleaned from the two sequences. We discuss topics including the analysis of the evolutionary forces shaping the size, structure and sequence of the genomes; the conservation of large-scale synteny across most of the genomes; the much lower extent of sequence orthology covering less than half of the genomes; the proportions of the genomes under selection; the number of protein-coding genes; the expansion of gene families related to reproduction and immunity; the evolution of proteins; and the identification of intraspecies polymorphism.
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