| First Author | Mao JH | Year | 2003 |
| Journal | Curr Opin Genet Dev | Volume | 13 |
| Issue | 1 | Pages | 14-9 |
| PubMed ID | 12573430 | Mgi Jnum | J:81525 |
| Mgi Id | MGI:2449500 | Doi | 10.1016/s0959-437x(03)00005-4 |
| Citation | Mao JH, et al. (2003) Genomic approaches to identification of tumour-susceptibility genes using mouse models. Curr Opin Genet Dev 13(1):14-9 |
| abstractText | Individual susceptibility to cancer in humans is determined by complex interactions between germline genetic variation and levels of exposure to environmental carcinogens or tumour promoters. Only a small fraction of cancer susceptibility is inherited in a Mendelian manner (high-penetrance familial cancer), and most tumours result from the combined effects of many gene-gene and gene-environment interactions. The sequencing of the mouse genome provides new approaches to one of the most challenging tasks of cancer genetics today. |
