| Primary Identifier | IPR030595 | Type | Family |
| Short Name | CCL5 |
| description | C-C chemokine ligand 5 (CCL5), also known as RANTES, is a target gene of NF-kappaB, and is expressed by T lymphocytes, macrophages, platelets, synovial fibroblasts, tubular epithelium, and certain types of tumour cells [, ]. CCL5 plays a role in recruiting a variety of leukocytes into inflammatory sites including T cells, macrophages, eosinophils, and basophils. CCL5 activity is mediated through its binding to CCR1, CCR3, and mainly CCR5 [, ].CCR5 is a G-protein-coupled receptor for CCL3, CCL4 and CCL5. CCR5 is also the major coreceptor for HIV-1 entry into target cells and is thought to be a suitable therapeutic target for HIV-1 blockade []. However, the affinity between CCR5 and natural CCL5 is low and has limited viral entry inhibiting activity. Therefore, several CCL5 derivatives with high anti-HIV-1 potency have been produced to act as entry inhibitors and CCR5 antagonists [, ]. |
