Primary Identifier | MGI:95816 | Organism | mouse, laboratory |
Chromosome | 4 | NCBI Gene Number | 14807 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential. Predicted to be involved in G protein-coupled glutamate receptor signaling pathway; glutamatergic synaptic transmission; and negative regulation of glutamatergic synaptic transmission. Predicted to act upstream of or within regulation of membrane potential. Located in plasma membrane. Is active in glutamatergic synapse. Is expressed in several structures, including chordamesoderm; future brain; gonad; retina; and spinal cord. Orthologous to human GRIK3 (glutamate ionotropic receptor kainate type subunit 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit significantly reduced short- and long-term synaptic potentiation. [provided by MGI curators] |