| First Author | Curtis PJ | Year | 1985 |
| Journal | Gene | Volume | 36 |
| Issue | 3 | Pages | 357-62 |
| PubMed ID | 3000887 | Mgi Jnum | J:8136 |
| Mgi Id | MGI:56605 | Doi | 10.1016/0378-1119(85)90191-x |
| Citation | Curtis PJ, et al. (1985) Sequence comparison of human and murine erythrocyte alpha-spectrin cDNA. Gene 36(3):357-62 |
| abstractText | The results of hybridization analyses using cDNA probes for mouse and human alpha-spectrin mRNA indicate that a single gene encodes the alpha-subunit of erythrocyte spectrin. Sequencing of the cDNA clones showed that they code for 370 amino acids (aa) covering three repeat domains close to the C terminus of alpha-spectrin. The cloned cDNAs will now permit the isolation of the alpha-spectrin gene and should lead to the characterization of the genetic aspects in human hereditary anemias in which alpha-spectrin has been characterized as the site of the molecular defect. |
