| Primary Identifier | MGI:96892 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 17096 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables SH3 domain binding activity; non-membrane spanning protein tyrosine kinase activity; and phosphatidylinositol 3-kinase activator activity. Involved in several processes, including immune response-regulating cell surface receptor signaling pathway; negative regulation of leukocyte proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; neuron projection development; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human LYN (LYN proto-oncogene, Src family tyrosine kinase). PHENOTYPE: Homozygotes for targeted null mutations exhibit splenomegaly, reduced numbers of peripheral B cells, impaired immune responses, IgM hyperglobulinemia, autoimmunity with glomerulonephritis, and monocyte/macrophage tumors. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
