| Primary Identifier | IPR039888 | Type | Family |
| Short Name | Melted-like |
| description | This entry includes protein melted from fruit flies and its homologues. They contain a single C-terminal PH domain that is required for membrane targeting. Melted interacts with both Tsc1 and FOXO and can recruit them to the cell membrane []. In vertebrates the melted protein homologue, veph, is expressed in the developing central nervous system []. The human homologue VEPH1 (ventricular zone-expressed PH domain-containing protein homologue 1) has been shown to inhibit TGF-beta signaling by impeding the release of activated SMAD2 from TbetaRI []. |
