| Primary Identifier | MGI:107405 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 13590 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables nodal binding activity. Involved in several processes, including negative regulation of nodal receptor complex assembly; negative regulation of nodal signaling pathway; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including anterior/posterior axis specification; cell migration involved in gastrulation; and response to retinoic acid. Located in extracellular region. Is expressed in several structures, including blastocyst; embryo mesoderm; gonad; neural ectoderm; and primitive streak. Orthologous to human LEFTY1 (left-right determination factor 1). PHENOTYPE: Mice homozygous for a null allele show embryonic and postnatal lethality, abnormal liver lobation, and a variety of left-right positional defects in visceral organs including left thoracic and atrial isomerism. A subset of mice homozygous for a differentnull allele show left pulmonary isomerism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
