| Type | MGI:General | Description | 16-20 week-old mice show significant impairment in glucose tolerance compared to wild-type fasted mice challenged with IP injection of glucose show insulin levels that are 2.5 fold higher in transgenic males than control males at 30 minutes post-injection; insulin levels are 37% higher at 30 minutes in transgenic females relative to wild-type glucose/insulin rario is lower in transgenic males after glucose challenge relative to wild-type; males have higher 30-minute glucose and insulin levels compared with females ability to dispose of intraperitoneally administered glucose load is markedly impaired in aged mice compared to sex- and age-matched controls |
