| First Author | Tzivion G | Year | 2006 |
| Journal | Semin Cancer Biol | Volume | 16 |
| Issue | 3 | Pages | 203-13 |
| PubMed ID | 16725345 | Mgi Jnum | J:111213 |
| Mgi Id | MGI:3653296 | Doi | 10.1016/j.semcancer.2006.03.004 |
| Citation | Tzivion G, et al. (2006) 14-3-3 proteins as potential oncogenes. Semin Cancer Biol 16(3):203-13 |
| abstractText | 14-3-3 proteins are a family of highly conserved cellular proteins that play key roles in the regulation of central physiological pathways. More than 200 14-3-3 target proteins have been identified, including proteins involved in mitogenic and cell survival signaling, cell cycle control and apoptotic cell death. Importantly, the involvement of 14-3-3 proteins in the regulation of various oncogenes and tumor suppressor genes points to a potential role in human cancer. The present review summarizes current findings implicating a 14-3-3 role in cancer while discussing potential mechanisms and points of action of 14-3-3 during cancer development and progression. |
