| First Author | Minocha S | Year | 2015 |
| Journal | Elife | Volume | 4 |
| PubMed ID | 26651999 | Mgi Jnum | J:269506 |
| Mgi Id | MGI:6208204 | Doi | 10.7554/eLife.09102 |
| Citation | Minocha S, et al. (2015) NG2 glia are required for vessel network formation during embryonic development. Elife 4:e09102 |
| abstractText | The NG2(+) glia, also known as polydendrocytes or oligodendrocyte precursor cells, represent a new entity among glial cell populations in the central nervous system. However, the complete repertoire of their roles is not yet identified. The embryonic NG2(+) glia originate from the Nkx2.1(+) progenitors of the ventral telencephalon. Our analysis unravels that, beginning from E12.5 until E16.5, the NG2(+) glia populate the entire dorsal telencephalon. Interestingly, their appearance temporally coincides with the establishment of blood vessel network in the embryonic brain. NG2(+) glia are closely apposed to developing cerebral vessels by being either positioned at the sprouting tip cells or tethered along the vessel walls. Absence of NG2(+) glia drastically affects the vascular development leading to severe reduction of ramifications and connections by E18.5. By revealing a novel and fundamental role for NG2(+) glia, our study brings new perspectives to mechanisms underlying proper vessels network formation in embryonic brains. |
