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Publication : Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein.

First Author  Sun D Year  1996
Journal  J Biol Chem Volume  271
Issue  39 Pages  24055-62
PubMed ID  8798642 Mgi Jnum  J:44778
Mgi Id  MGI:1101294 Doi  10.1074/jbc.271.39.24055
Citation  Sun D, et al. (1996) Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem 271(39):24055-62
abstractText  Previously, we isolated the murine leukocyte-type 12-lipoxygenase (L-12LO) cDNA from RNA of peritoneal-elicited cells that consisted predominantly of leukocytes (Chen, X.-S., Kurre, U., Jenkins, N. A., Copeland, N. G., and Funk, C. D. (1994) J. Biol. Chem. 269, 13979-13987). By in situ hybridization we show that the L-12LO gene is expressed abundantly in a subset of peritoneal macrophages but not in elicited leukocytes,
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