| First Author | Klein RF | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5655 | Pages | 229-32 |
| PubMed ID | 14716014 | Mgi Jnum | J:87403 |
| Mgi Id | MGI:2686849 | Doi | 10.1126/science.1090985 |
| Citation | Klein RF, et al. (2004) Regulation of bone mass in mice by the lipoxygenase gene Alox15. Science 303(5655):229-32 |
| abstractText | The development of osteoporosis involves the interaction of multiple environmental and genetic factors. Through combined genetic and genomic approaches, we identified the lipoxygenase gene Alox15 as a negative regulator of peak bone mineral density in mice. Crossbreeding experiments with Alox15 knockout mice confirmed that 12/15-lipoxygenase plays a role in skeletal development. Pharmacologic inhibitors of this enzyme improved bone density and strength in two rodent models of osteoporosis. These results suggest that drugs targeting the 12/15-lipoxygenase pathway merit investigation as a therapy for osteoporosis. |
