| Primary Identifier | IPR028667 | Type | Family |
| Short Name | SNX27 |
| description | Sorting nexin-27 (SNX27) belongs to the sorting nexin family, which contains a conserved PX (phox homology) domain that may be responsible for binding to specific phosphoinositides []. SNX27 also possesses an PDZ (DHR) domain, a Ras-associating domain and a FERM-like domain with an atypical tertiary structure [].SNX27 is a core component of the SNX27-retromer, a multiprotein complex composed of SNX27, the WASH complex and the retromer complex. It specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C terminus []. Its PDZ domain mediates binding to the retromer complex via direct interaction with VPS26 (VPS26A or VPS26B) [], while its PX domain mediates binding to phosphatidylinositol 3-phosphate (PtdIns(3P)) and localization to early endosome membranes []. |
