| First Author | Scott DM | Year | 1995 |
| Journal | Nature | Volume | 376 |
| Issue | 6542 | Pages | 695-8 |
| PubMed ID | 7544442 | Mgi Jnum | J:28422 |
| Mgi Id | MGI:76040 | Doi | 10.1038/376695a0 |
| Citation | Scott DM, et al. (1995) Identification of a mouse male-specific transplantation antigen, H-Y [see comments]. Nature 376(6542):695-8 |
| abstractText | The male-specific transplantation antigen, H-Y, causes rejection of male tissue grafts by genotypically identical female mice and contributes to the rejection of human leukocyte antigen-matched male organ grafts by human females. Although first recognized 40 years ago, the identity of H-Y has remained elusive. T cells detect several distinct H-Y epitopes, and these are probably peptides, derived from intracellular proteins, that are presented at the cell surface with major histocompatibility complex (MHC) molecules. In the mouse, the gene(s) controlling H-Y expression (Hya) are located on the short arm of the Y chromosome between the zinc-finger genes Zfy-1 and Zfy-2. We have recently identified Smcy, a ubiquitously expressed gene, in this region and its X-chromosome homologue, Smcx. Here we report that Smcy encodes an H-YKk epitope that is defined by the octamer peptide TENSGKDI: no similar peptide is found in Smcx. These findings provide a genetic basis for the antigenic difference between males and females that contributes towards a tissue transplant rejection response. |
