| Primary Identifier | IPR005656 | Type | Family |
| Short Name | MmgE_PrpD |
| description | This entry represents proteins from the MmgE/PrpD family, which includes 2-methylcitrate dehydratase (PrpD; ). PrpD is required for propionate catabolism, catalysing the third step of the 2-methylcitric acid cycle []. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha+beta domain []. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family. CAD is essential for itaconic acid production in Aspergillus terreus []. Citrate/2-methylcitrate dehydratase from Bacillus subtilis is involved in the tricarboxylic acid (TCA) and methylcitric acid cycles as it has both 2-methylcitrate dehydratase and citrate dehydratase activities []. |
