| Primary Identifier | MGI:103290 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 19697 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and ankyrin repeat binding activity. Involved in several processes, including negative regulation of protein sumoylation; positive regulation of canonical NF-kappaB signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including cellular response to hepatocyte growth factor stimulus; negative regulation of extrinsic apoptotic signaling pathway; and positive regulation of interleukin-12 production. Located in cytosol and nucleus. Part of NF-kappaB p50/p65 complex; chromatin; and transcription regulator complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; musculature; and skin. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). PHENOTYPE: Homozygous null mice are embryonic lethal due to hepatic apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
