Primary Identifier | MGI:1354950 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 641340 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable nuclear receptor binding activity and transcription coactivator activity. Involved in autophagy and response to endoplasmic reticulum stress. Part of phosphatidylinositol 3-kinase complex, class III. Orthologous to human NRBF2 (nuclear receptor binding factor 2). PHENOTYPE: Mice homozygous null for this allele develop focal liver necrosis and ductular reaction in the liver and cells show impaired autophagosome maturation and increased susceptibility to ER stress. [provided by MGI curators] |