| First Author | Schreiber KL | Year | 1989 |
| Journal | Transplantation | Volume | 48 |
| Issue | 2 | Pages | 331-8 |
| PubMed ID | 2787938 | Mgi Jnum | J:9904 |
| Mgi Id | MGI:58361 | Doi | 10.1097/00007890-198908000-00028 |
| Citation | Schreiber KL, et al. (1989) Developmental coupling of expression of the Igh-linked minor antigen H-40 to membrane immunoglobulin expression. Transplantation 48(2):331-8 |
| abstractText | C.B-20 (Ighb) but not BALB/c (Igha) mice are able to reject BCL1, a spontaneous B cell leukemia of BALB/c origin. The protective immune response is directed toward the minor histocompatibility (H) antigen, H-40, which can be detected by cytotoxic T lymphocytes and is expressed on surface (s) immunoglobulin positive tumor cells including BCL1 as well as sIg+ lymphoblasts activated by lipopolysaccharide. The fact that only sIg+ tumor cells and lymphoblasts express H-40 suggests that sIg itself may be a component involved in CTL recognition of this antigen. However, this possibility was ruled out by demonstrating that removal of sIg from target cells did not prevent H-40-specific CTL recognition. To determine whether H-40 expression was coordinately regulated with that of membrane Ig, we determined whether H-40- sIg- cells acquire H-40 when induced to express sIg. We also transfected a functional mu c and nu region gene into a sIg- lymphoma so that it acquired a sIg+ phenotype. In neither case did such sIg+ cells acquire H-40. Together, these data indicate that H-40 is expressed on B cells representing a particular stage of differentiation that is coincidental with sIg. We previously showed that H-40 and Igh loci are linked on the 12th murine chromosome. In this study we further localized H-40 to a point beyond Aat (formerly Pre-1) near Lm-1, a locus previously described to encode minor H-antigens expressed on lymphomyeloid cells. Thus, H-40 and Lm-1 may represent a gene cluster encoding antigens expressed on subsets of lymphoid and myeloid cells. |
