| First Author | Ciurea A | Year | 2001 |
| Journal | Nat Med | Volume | 7 |
| Issue | 7 | Pages | 795-800 |
| PubMed ID | 11433343 | Mgi Jnum | J:134010 |
| Mgi Id | MGI:3784767 | Doi | 10.1038/89915 |
| Citation | Ciurea A, et al. (2001) CD4+ T-cell-epitope escape mutant virus selected in vivo. Nat Med 7(7):795-800 |
| abstractText | Mutations in viral genomes that affect T-cell-receptor recognition by CD8+ cytotoxic T lymphocytes have been shown to allow viral evasion from immune surveillance during persistent viral infections. Although CD4+ T-helper cells are crucially involved in the maintenance of effective cytotoxic T-lymphocyte and neutralizing-antibody responses, their role in viral clearance and therefore in imposing similar selective pressures on the virus is unclear. We show here that transgenic virus-specific CD4+ Tcells, transferred into mice persistently infected with lymphocytic choriomeningitis virus, select for T-helper epitope mutant viruses that are not recognized. Together with the observed antigenic variation of the same T-helper epitope during polyclonal CD4+ T-cell responses in infected pore-forming protein-deficient C57BL/6 mice, this finding indicates that viral escape from CD4+ T lymphocytes is a possible mechanism of virus persistence. |
