| First Author | Kawabe H | Year | 2010 |
| Journal | Neuron | Volume | 65 |
| Issue | 3 | Pages | 358-72 |
| PubMed ID | 20159449 | Mgi Jnum | J:164745 |
| Mgi Id | MGI:4835109 | Doi | 10.1016/j.neuron.2010.01.007 |
| Citation | Kawabe H, et al. (2010) Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development. Neuron 65(3):358-72 |
| abstractText | Nedd4-1 is a 'neuronal precursor cell expressed and developmentally downregulated protein' and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4-1-deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity of Rap2 effector kinases of the TNIK family and promotes dendrite growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons. |
