Primary Identifier | MGI:1927664 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 64383 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables beta-tubulin binding activity; histone deacetylase activity; and tubulin deacetylase activity. Involved in several processes, including positive regulation of cell cycle process; regulation of gene expression; and regulation of protein metabolic process. Acts upstream of or within chromatin organization; negative regulation of NLRP3 inflammasome complex assembly; and regulation of fat cell differentiation. Located in several cellular components, including Schmidt-Lanterman incisure; paranodal junction; and perikaryon. Is expressed in several structures, including brain; liver; oocyte; sensory organ; and spinal cord. Orthologous to human SIRT2 (sirtuin 2). PHENOTYPE: Mice homozygous for a floxed allele activated in Schwann cells exhibit delayed myelination during development and following a nerve crush injury. Mice homozygous for a knock-out allele exhibit increased tumor formation and abnormal mitosis. [provided by MGI curators] |