| Primary Identifier | IPR030476 | Type | Conserved_site |
| Short Name | Pentaxin_CS |
| description | Pentaxins (or pentraxins) [, ]are a family of proteins which show, underelectron microscopy, a discoid arrangement of five noncovalently boundsubunits. Proteins known to belong to this family are:C-reactive protein (CRP), a protein which, in mammals,is expressed duringacute phase response to tissue injury or inflammation. CRP displays severalfunctions associated with host defense: it promotes agglutination,bacterial capsular swelling, phagocytosis and complement fixation throughits calcium-dependent binding to phosphorylcholine. CRPs have also beensequenced in an invertebrate, the Atlantic horseshoe crab, where they are anormal constituent of the hemolymph.Serum Amyloid P-component (SAP), a precursor of amyloid component P whichis found in basement membrane and is associated with amyloid deposits.Hamster female protein (FP), a plasma protein whose concentration isaltered by sex steroids and stimuli that elicit an acute phase response.A number of proteins, whose function is not yet clear, contain a C-terminalpentaxin-like domain. These proteins are:Human PTX3 (or TSG-14). PTX3 is a cytokine-induced protein.Guinea pig apexin [], a sperm acrosomal protein. Apexin seems to be theortholog of human neuronal pentraxin II (gene NPTX2) [].Rat neuronal pentaxin I [].The sequences of the different members of this family are quite conserved. This entry represents a six residue pattern which includes a cysteineknown to be involved in a disulfide bridge in CRPs and SAP. |
